N-Methylformamide (NMF)
High-Purity Polar Aprotic Solvent & Formylation Reagent — Pharma, Electronic & Agrochemical Synthesis
CAS: 123-39-7 EC: 204-624-6 Assay: ≥ 99.5%
N-Methylformamide (NMF, monomethylformamide, CAS 123-39-7) is a high-polarity amide solvent and versatile reagent — one of the most polar common organic solvents (dielectric constant ≈ 182), with strong solvating power for salts and polar intermediates. It serves as a solvent and formylating/amidation reagent in pharmaceutical API synthesis, an electrolyte solvent for aluminium electrolytic capacitors and electronic chemicals, and an intermediate in agrochemical production. Royalchem supplies it at ≥ 99.5% purity with tightly controlled methanol, DMF, and free-alkali impurities, as a colourless transparent liquid in drums or IBCs.
Technical Specifications (COA Data)
| Assay (GC) | ≥ 99.5% |
| Appearance / Colour (APHA) | Colourless transparent liquid / ≤ 10 |
| Moisture (KF) | ≤ 0.05% |
| Methanol / DMF | ≤ 0.1% / ≤ 0.5% |
| Free Alkali | ≤ 0.005% |
| Molecular Weight / Density (20 °C) | 59.07 g/mol / ≈ 1.011 g/mL |
| Boiling Point / Flash Point | ≈ 182–184 °C / ≈ 111 °C |
*Regulatory: EINECS-listed (EC 204-624-6); REACH-registered; manufactured under ISO 9001. GHS — Danger: may damage the unborn child (H360D, Repr. 1B); harmful in contact with skin (H312) — readily absorbed through skin. For industrial/professional use only; pregnant workers must not be exposed. Not classified as dangerous goods for transport. Handle in closed systems or with impervious gloves, eye protection, and effective ventilation. Always refer to the current SDS.
Key Properties
• Molecular Formula: C₂H₅NO (HCONHCH₃)
• Molecular Weight: 59.07
• Boiling Point: ≈ 182–184 °C
• Dielectric Constant: ≈ 182 (very high)
Pharmaceutical & Organic Synthesis
A polar reaction solvent and formylation/amidation reagent in API manufacture, a precursor to methyl isocyanide, and a medium for salt-demanding transformations that ordinary solvents cannot dissolve.
Electronic Chemicals
An electrolyte solvent for aluminium electrolytic capacitors and a process solvent in semiconductor and electronic-component manufacturing, valued for its very high dielectric constant and thermal stability.
Agrochemicals & Extraction
An intermediate in pesticide and herbicide synthesis, and a selective extraction solvent for aromatic hydrocarbons in refinery and analytical separation processes.