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| Model: | Pharma Grade ≥99% |
|---|---|
| Brand: | Royalchem |
| Code: | 2934.10 |
| CAS NO.: | 121-66-4 |
| Quantity: | |
2-Amino-5-Nitrothiazole
2-Amino-5-nitrothiazole (ANT; 5-nitro-1,3-thiazol-2-amine; 5-nitro-2-thiazolylamine; CAS 121-66-4; EC 204-490-9) is a high-purity yellow crystalline nitrothiazole (C₃H₃N₃O₂S, molecular weight 145.14, melting point 195–200 °C dec.) supplied by Royalchem Spain at ≥99% purity (HPLC). As the key amine building block of nitazoxanide — a broad-spectrum antiparasitic and antiviral API — and of related nitrothiazole actives, it is widely used in pharmaceutical synthesis and antimicrobial research, and also serves as a diazo component for disperse azo dyes (blues and violets) used in synthetic-fibre dyeing.
Product Description
2-Amino-5-Nitrothiazole (ANT)
High-Purity Nitrothiazole Intermediate — Key Building Block for Nitazoxanide & Antimicrobial APIs and Disperse Azo Dyes
CAS: 121-66-4 EC: 204-490-9 Assay: ≥ 99.0%
2-Amino-5-nitrothiazole (ANT; 5-nitro-1,3-thiazol-2-amine; 5-nitro-2-thiazolylamine; CAS 121-66-4) is a high-purity yellow crystalline nitrothiazole and a key pharmaceutical and dye intermediate. As the amine building block of nitazoxanide — a broad-spectrum antiparasitic and antiviral API — and of related nitrothiazole actives, it is widely used in pharmaceutical synthesis and research, and also serves as a diazo component for disperse azo dyes (blues and violets) used in synthetic-fibre dyeing. Royalchem Spain supplies it at ≥ 99% purity (HPLC) as a light-yellow to yellow crystalline powder, delivered from our Valladolid distribution hub by bag or drum with COA and SDS for every batch.
Technical Specifications (COA Data)
| Assay (HPLC) | ≥ 99.0% |
| Appearance | Light-yellow to yellow crystalline powder |
| Melting Point | 195–200 °C (decomposition) |
| Solubility | Insoluble in water; soluble in DMF / DMSO |
| Molecular Weight | 145.14 g/mol |
| Light Sensitivity | Protect from light |
*Regulatory: EINECS-listed (EC 204-490-9); supplied in line with EU REACH requirements; manufactured under ISO 9001. GHS — Warning: harmful if swallowed (H302); causes skin and serious eye irritation (H315, H319); may cause respiratory irritation (H335). Several suppliers also flag it as suspected of causing cancer (H351, Carc. 2), though IARC lists it as Group 3 (not classifiable as to carcinogenicity) — verify the applicable classification. Light-sensitive; keep away from strong acids and oxidising agents. Generally not a transport-regulated dangerous good — confirm against the current SDS. Use gloves, eye protection, and ventilation, and avoid dust. Always refer to the current SDS.
Chemical Structure
Key Properties
• Molecular Formula: C₃H₃N₃O₂S
• Molecular Weight: 145.14
• Melting Point: 195–200 °C (dec.)
• Synonyms: ANT, 5-nitro-2-thiazolylamine
• Molecular Weight: 145.14
• Melting Point: 195–200 °C (dec.)
• Synonyms: ANT, 5-nitro-2-thiazolylamine
Main Applications
Pharmaceutical Synthesis
The key amine intermediate for nitazoxanide — a broad-spectrum antiparasitic and antiviral API used against Giardia, Cryptosporidium, and other intestinal infections — and for related nitrothiazole actives.
R&D & Antimicrobial Discovery
A building block for nitrothiazole analogues studied for activity against Helicobacter pylori, Clostridium difficile, and Campylobacter jejuni, and explored as a hypoxic radiosensitiser in oncology research.
Dye Intermediate
A diazo component for the synthesis of disperse azo dyes (such as Disperse Blue and Disperse Violet) used in the textile dyeing of synthetic fibres.
Logistics & Packaging
Standard Packaging:
25 kg fiber drums, cartons, or kraft-paper bags — or to customer requirement. Distributed by Royalchem Spain from our Valladolid hub. Shelf life 24 months in original sealed packaging.
Storage Conditions:
Store in a cool, dry, well-ventilated area, protected from direct light, with containers tightly closed. Keep away from strong acids and strong oxidising agents, and minimise dust generation during handling.