Phone:
34-686341722
3,5-Dichlorobenzoyl Chloride
3,5-Dichlorobenzoyl chloride (3,5-DCBC; CAS 2905-62-6; EC 220-813-6) is a high-purity, reactive acyl chloride (C₇H₃Cl₃O, molecular weight 209.46 g/mol, melting point 26–28 °C, boiling point ≈249 °C) supplied by Royalchem Spain at ≥98% purity (HPLC). Its activated carbonyl readily undergoes Friedel–Crafts acylation and amide/ester formation, making it a key building block for the dry-eye drug lifitegrast, the herbicides propyzamide and oxaziclomefone, dichlorobenzamide derivatives, and specialty fine chemicals.
Product Description
3,5-Dichlorobenzoyl Chloride (3,5-DCBC)
High-Purity Reactive Acyl Chloride — Pharmaceutical (Lifitegrast) & Agrochemical (Propyzamide, Oxaziclomefone) Synthesis Intermediate
CAS: 2905-62-6 EC: 220-813-6 Assay: ≥ 98.0%
3,5-Dichlorobenzoyl chloride (3,5-DCBC, CAS 2905-62-6) is a high-purity, reactive acyl chloride and a key building block for pharmaceutical and agrochemical synthesis. Its activated carbonyl readily undergoes Friedel–Crafts acylation and amide/ester formation, making it a valued intermediate for the dry-eye drug lifitegrast, the herbicides propyzamide and oxaziclomefone, dichlorobenzamide derivatives, and specialty fine chemicals. A low-melting solid that is liquid near room temperature, it is moisture-sensitive and corrosive. Royalchem Spain supplies it at ≥ 98% purity (HPLC) as a colourless-to-yellow material, delivered from our Valladolid distribution hub under dry conditions by drum.
Technical Specifications (COA Data)
| Assay (HPLC) | ≥ 98.0% |
| Appearance | Low-melting solid / clear liquid |
| Colour (Pt–Co) | Colourless to yellow |
| Water (KF) | ≤ 0.05% |
| Isomers (2,4- / 3,4-DCBC) | ≤ 0.10% / ≤ 0.20% |
| Heavy Metals | ≤ 10 ppm |
| Molecular Weight | 209.46 g/mol |
| Melting Point | ≈ 26–28 °C |
*Regulatory: EINECS-listed (EC 220-813-6); supplied in line with EU REACH requirements; manufactured under ISO 9001. GHS — Danger: harmful if swallowed (H302); causes severe skin burns and eye damage (H314). As an acyl chloride it reacts with water and moist air, liberating corrosive hydrogen chloride (HCl) — keep strictly anhydrous. Shipped as a Class 8 corrosive substance (typically UN 3265, PG II) — confirm against the current SDS. Handle under dry conditions with full PPE (gloves, goggles/face shield) and effective ventilation. Always refer to the current SDS.
Chemical Structure
Key Properties
• Molecular Formula: C₇H₃Cl₃O
• Molecular Weight: 209.46
• Boiling Point: ≈ 249 °C
• Density (20 °C): ≈ 1.50 g/cm³
• Molecular Weight: 209.46
• Boiling Point: ≈ 249 °C
• Density (20 °C): ≈ 1.50 g/cm³
Main Applications
Pharmaceutical Intermediate
A reactive acyl building block for active pharmaceutical ingredients, used in the synthesis of the dry-eye drug lifitegrast and in the preparation of dichlorobenzamide derivatives by reaction with amines — a versatile route to substituted benzamides and benzoate esters.
Agrochemical Intermediate
A key building block for crop-protection actives, notably the selective pre-emergence herbicide propyzamide (pronamide) and the herbicide oxaziclomefone, as well as other amide-based agrochemicals.
Acylation Building Block
A general-purpose acylating agent for Friedel–Crafts acylation and for amide and ester formation, used to introduce the 3,5-dichlorobenzoyl group into dyes, ligands, and specialty fine-chemical molecules.
Logistics & Packaging
Standard Packaging:
250 kg HDPE or steel drums, or to customer requirement, filled under dry nitrogen. Distributed by Royalchem Spain from our Valladolid hub. Shelf life 12 months in original sealed, dry packaging.
Storage Conditions:
Store in tightly sealed containers in a cool, dry, well-ventilated area, strictly away from water, moisture, alcohols, amines, bases, and oxidising agents; nitrogen blanketing is recommended. Moisture-sensitive and corrosive — it hydrolyses on contact with water or humid air, releasing hydrogen chloride.