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4-Methylenepiperidine hydrochloride (CAS 144230-50-2) is the stable, easy-to-handle hydrochloride salt of 4-methylenepiperidine, a secondary cyclic amine bearing a reactive exocyclic methylene group. It is best known as the key piperidine intermediate in the synthesis of efinaconazole — the triazole antifungal (Jublia®) used to treat onychomycosis — and serves more broadly as a building block in antifungal R&D and medicinal chemistry. Royalchem Spain supplies it at ≥ 98% purity as an off-white to pale-yellow powder, delivered from our Valladolid distribution hub in lined drums or boxed bags.
| Assay (HPLC) | ≥ 98.0% |
| Appearance | Off-white to pale-yellow powder |
| Water Content (KF) | ≤ 2.0% |
| Molecular Weight | 133.62 g/mol |
| Molecular Formula | C₆H₁₂ClN (C₆H₁₁N·HCl) |
| Solubility | Soluble in water and methanol |
| Single Largest Impurity | Conforms to in-house standard |
The key piperidine intermediate for efinaconazole, the topical triazole antifungal for onychomycosis: its exocyclic methylene is incorporated directly into the API's 4-methylenepiperidin-1-yl moiety in the final coupling step.
Supplied with full batch documentation and impurity profiling to support commercial API production, quality-control reference work, and ANDA/generic regulatory filings by antifungal manufacturers.
A versatile secondary-amine building block with a reactive alkene handle for drug-discovery programmes, triazole-antifungal analogue research, and broader heterocyclic and fine-chemical synthesis.
Standard Packaging:
1 kg / 5 kg foil bags or 25 kg lined fibre drums — or to customer requirement. Distributed by Royalchem Spain from our Valladolid hub. Shelf life 24 months in original sealed packaging.
Storage Conditions:
Store in tightly sealed containers in a cool, dry, well-ventilated area, protected from light, moisture, and oxidising agents — the hydrochloride salt is hygroscopic and should be resealed promptly under dry conditions (nitrogen recommended for opened containers).