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N-Methylformamide NMF CAS 123-39-7 chemical structure C2H5NO, polar solvent for pharma and electronics

CAS NO.:	123-39-7
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N-Methylformamide

N-Methylformamide (NMF, monomethylformamide, CAS 123-39-7, EC 204-624-6) is a high-polarity amide solvent and formylation reagent supplied by Royalchem Spain at ≥99.5% purity with controlled methanol (≤0.1%), DMF (≤0.5%) and free alkali (≤0.005%). It is used in pharmaceutical API synthesis, as an electrolyte solvent for aluminium electrolytic capacitors and electronic chemicals, in agrochemical production, and for aromatic extraction.

Product Description

N-Methylformamide (NMF)

High-Purity Polar Aprotic Solvent & Formylation Reagent — Pharma, Electronic & Agrochemical Synthesis

CAS: 123-39-7 EC: 204-624-6 Assay: ≥ 99.5%

N-Methylformamide (NMF, monomethylformamide, CAS 123-39-7) is a high-polarity amide solvent and versatile reagent — one of the most polar common organic solvents (dielectric constant ≈ 182), with strong solvating power for salts and polar intermediates. It serves as a solvent and formylating/amidation reagent in pharmaceutical API synthesis, an electrolyte solvent for aluminium electrolytic capacitors and electronic chemicals, and an intermediate in agrochemical production. Royalchem supplies it at ≥ 99.5% purity with tightly controlled methanol, DMF, and free-alkali impurities, as a colourless transparent liquid in drums or IBCs.

Technical Specifications (COA Data)

Assay (GC)	≥ 99.5%
Appearance / Colour (APHA)	Colourless transparent liquid / ≤ 10
Moisture (KF)	≤ 0.05%
Methanol / DMF	≤ 0.1% / ≤ 0.5%
Free Alkali	≤ 0.005%
Molecular Weight / Density (20 °C)	59.07 g/mol / ≈ 1.011 g/mL
Boiling Point / Flash Point	≈ 182–184 °C / ≈ 111 °C

*Regulatory: EINECS-listed (EC 204-624-6); REACH-registered; manufactured under ISO 9001. GHS — Danger: may damage the unborn child (H360D, Repr. 1B); harmful in contact with skin (H312) — readily absorbed through skin. For industrial/professional use only; pregnant workers must not be exposed. Not classified as dangerous goods for transport. Handle in closed systems or with impervious gloves, eye protection, and effective ventilation. Always refer to the current SDS.

Chemical Structure

Key Properties

• Molecular Formula: C₂H₅NO (HCONHCH₃)
• Molecular Weight: 59.07
• Boiling Point: ≈ 182–184 °C
• Dielectric Constant: ≈ 182 (very high)

Main Applications

Pharmaceutical & Organic Synthesis

A polar reaction solvent and formylation/amidation reagent in API manufacture, a precursor to methyl isocyanide, and a medium for salt-demanding transformations that ordinary solvents cannot dissolve.

Electronic Chemicals

An electrolyte solvent for aluminium electrolytic capacitors and a process solvent in semiconductor and electronic-component manufacturing, valued for its very high dielectric constant and thermal stability.

Agrochemicals & Extraction

An intermediate in pesticide and herbicide synthesis, and a selective extraction solvent for aromatic hydrocarbons in refinery and analytical separation processes.

Logistics & Packaging

Standard Packaging:

200 kg HDPE or steel drums, or 1000 kg IBC totes — or to customer requirement. Distributed by Royalchem Spain from our Valladolid hub. Shelf life 24 months in original sealed packaging.

Storage Conditions:

Store in tightly sealed containers in a cool, dry, well-ventilated area away from heat, ignition sources, strong oxidisers, and acids. NMF is hygroscopic — keep dry (nitrogen blanket recommended for electronic grade) and reseal promptly. Restrict access to trained personnel; avoid all skin contact.

Pharmaceutical Intermediates N-Methylformamide monomethylformamide electronic grade solvent solvent