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Chlorosulfonyl isocyanate/ CSI Molecular Structure

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CAS NO.: 1189-71-5
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Chlorosulfonyl Isocyanate/ CSI

Product Description

 Product Name

 Chlorosulfonyl isocyanate/ CSI

 CAS NO.

 1189-71-5

 Molecular Formula

 ClSO₂NCO

 Structural Formula

1189-71-5

 Molecular Weight

 141.53 g/mol

 Purity

  99.0% min 

Impurity  0.6% max
Density  1.626 g/mL
Appearance  Colorless transparent liquid

 Application

Primary Application: β-Lactam Antibiotic Synthesis

Essential reagent for cephalosporin synthesis (Cefuroxime, Cefoxitin) and other β-lactam antibiotics.


Cephalosporin Synthesis
• Cefuroxime intermediate production
• Cefoxitin synthesis pathway
• Second & third-generation cephalosporins


β-Lactam Formation
• [2+2] Cycloaddition reactions
• N-chlorosulfonyl-β-lactams synthesis
• Stereoselective β-lactam preparation
• Novel antibiotic scaffolds


⚗️ Sulfamide Chemistry
• Sulfamoyl carbamate formation
• Bioisosteric replacements
• N,N-disubstituted sulfamides
• Medicinal chemistry applications


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